Immunology Research

Immunology Research

The only time it’s not weird to say “I love cancer”

Applying Systems Immunology Approaches to understand Cancer and Autoimmunity


As a hopeful physician-scientist, my research interests center around translational approaches; emphasizing on bringing the research I do from the bench to the bedside. I’m highly interested in cancer immunology and cancer immunotherapy research that combines a systems and public health approach. I’m also interested in studying autoimmune diseases such as Lupus and MS and understanding how to apply methods of cancer immunotherapy to target some of inflammatory activity that defines many of these autoimmune diseases.

A full summary of my research experience is in my CV, though, I also want to emphasize and highlight the challenge of my research journey, especially as a first-generation, low-income student and a Black Woman in STEM. I’m very thankful for the PIs who have supported my journey, though there is so much more that the academic science world (and the non-academic world too) needs to do to insure that students like me are able to make careers in science accessible, specifically addressing and supporting efforts that are often led by historically excluded students like myself, to address the racial and financial barriers present in the path of succeeding in academia.

I look forward to using my experiences and my stories to grow and hopefully be an inspiration to other students who come from historically excluded groups in the sciences.

Exploring the role of B Cells in Kidney Transplant Acute Rejection

Some studies suggest poorer graft survival associated with B cell infiltrates in biopsies diagnosed with cellular rejection, whereas others have not. Furthermore, the specificity of the B cell infiltrates has not been well characterized. Previous studies with explants from human kidney transplant recipient suggest polyreactive nature of these B cells. However, their kinetics and subsequent contribution to the allograft rejection has not been studied. In this study, we aimed to study the kinetics of the polyreactive antibodies in a mouse model of kidney transplant rejection. I performed multiple enzyme-linked immunosorbent assays (ELISA) to test the specificity of serum samples from mice transplant recipients collected at different time point post-transplant, against diverse groups of antigens ie. self, donor and third-party antigens. Using this assay was essential in contributing to our understanding of graft infiltrating B cells in transplant rejection.

Research Conducted as a Katen Scholar Research Fellow in the Chong Lab at the University of Chicago

Characterizing the role of Cancer Associated Fibroblasts in the progression of Ovarian Cancer

The crosstalk between tumors cells and cancer associated fibroblasts (CAFs) that are activated in the tumor microenvironment (TME) support cancer progression by promoting angiogenesis and suppressing of anti-tumor immune responses. Using single-cell RNA sequencing (scRNA-seq) of 12 patients with ovarian cancer and R programming, at the time of study, I was able to identify identify six molecular sub-types of fibroblasts in tumors resected from primary and metastatic sites. Differential expression analysis indicate that four of these subtypes contain genetic markers exhibited by CAF via elevated expression of IL-6, TNF, VEGFA and NF-kB. These CAF markers were highly cluster and site (primary vs. metastatic) specific. Further investigation into primary versus metastatic site-specific CAFs may progress our understanding of the role of CAFs in cancer progression and metastasis, and may reveal a novel target in fighting ovarian cancer.

Research supported by a two year Jeff Metcalf Research Fellowship Award and conducted as an undergraduate research assistant in the Basu Lab at the University of Chicago

Understanding the role of Dendritic Cells and activation of B And T Lymphocytes in Breast Cancer

Despite the significance that checkpoint inhibitor (ICI) therapy has brought in the fight against cancer, many patient tumors, including those with high T cell infiltration, remain resistant to checkpoint therapy and continue to experience other dysfunctions in their immune response to cancer. Within the multiple projects I am currently working on in the lab, I am using mouse models of triple negative breast cancer and a secondary immune stimulus via listeria to understand how cancer disrupts normal immune response function via dendritic cell, MHC Class I and T cell activation. Taking a systems immunology approach using techniques such as Mass Cytometry by Flight (CyTOF), Multiplex Ion Beam Imaging (MIBI), Immunohisochemistry (IHC) and single cell RNA-sequencing (sc-RNA seq), we have been able to create a comprehensive immune profile of the tumor microenvironment and peripheral sites and look forward to identifying novel mechanisms that will be essential in the fight against cancer.

Research conducted as PROPEL Post-Baccalaureate Scholar and ImmunoX ImmunoDiverse Fellow in the Spitzer Lab at the University of California, San Francisco